In Nigeria, the foundation of serious sacred or liturgical musical knowledge and practice is mostly laid and grown in local churches, where many choir leaders who provide musical guidance lack formal music training. As a result, limited musical knowledge is passed down to the soloists and the accompanists they lead. Having noted this inadequacy as it affects the interpretation of serious vocal forms such as arias, this study aims to provide a performance interpretation framework, serving as a practical and creative guide among church musicians in Nigeria. The study adopts a qualitative descriptive-analytical research methodology grounded in performance practice and interpretative musicology. The study provides a technically grounded review and stylistically compelling performance interpretation of Handel’s O Thou That Tellest Good Tidings to Zion, highlighting critical areas for technical emphasis and improvement in performance practice within Nigerian churches. The study concludes that technical competence is a sine qua non for effective performance interpretation of any set art musical piece, and offers recommendations to enhance expressive delivery of the piece, taking into account the background of the composition and its liturgical essence.